Molecular Interaction and Inhibitory Potential of Polyphenol on DNA Repair Pathway in Small Cell Lung Cancer: A Computational Study
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چکیده
Small cell lung cancer (SCLC), is a highly aggressive pulmonary neuroendocrine neoplasm which represents about 20% of all lung carcinoma [1] cases with an ever increasing proliferative index and an unusually strong predilection towards metastasis [2,3]. Despite the unceasing basic and clinical research that started about 30 years [4] no sustainable improvements have been established in the treatment of this pulmonary insult. Human SCLC is currently ranked as the leading cause of cancer-death worldwide with annual mortality rate. However, several attempts have been geared at understanding the molecular mechanisms that underpin the pathogenesis of human SCLC.
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تاریخ انتشار 2017